Title
Hydra as a tractable, long-lived model system for senescence
Document Type
Article
Publication Title
Invertebrate Reproduction and Development
Publication Date
1-30-2015
Abstract
Hydra represents a unique model system for the study of senescence, with the opportunity for the comparison of non-aging and induced senescence. Hydra maintains three stem cell lineages, used for continuous tissue morphogenesis and replacement. Recent work has elucidated the roles of the insulin/IGF-1 signaling target FoxO, of Myc proteins, and of PIWI proteins in Hydra stem cells. Under laboratory culture conditions, Hydra vulgaris show no signs of aging even under long-term study. In contrast, Hydra oligactis can be experimentally induced to undergo reproduction-associated senescence. This provides a powerful comparative system for future studies.
Volume
59
First Page
39
Last Page
44
DOI
10.1080/07924259.2014.938196
ISSN
07924259
Recommended Citation
Bellantuono, Anthony J.; Bridge, Diane; and Martínez, Daniel E., "Hydra as a tractable, long-lived model system for senescence" (2015). Faculty Publications. 1137.
https://jayscholar.etown.edu/facpubharvest/1137
