Synthesis and small molecule exchange studies of a magnesium bisformate metal-organic framework: An experiment in host-guest chemistry for the undergraduate laboratory

Jeffrey A. Rood, Elizabethtown College
Kenneth W. Henderson, University of Notre Dame


Experiments are described that introduce students to the important concepts of host-guest chemistry and size exclusion in porous metal-organic frameworks (MOFs). The experiment has been successfully carried out in both introductory and advanced-level inorganic chemistry laboratories. Students synthesized the porous MOF, α-Mg (O CH) , and examined its ability to take up a variety of small organic molecules into its pores using H NMR spectroscopy. The MOF exhibited size exclusion and students rationalized this behavior based on the structures of the organic molecules and the pore size of the MOF. © 2012 The American Chemical Society and Division of Chemical Education, Inc. 3 2 6 1