Document Type



Summer 2021

Academic Department

Chemistry and Biochemistry

Faculty Advisor(s)

Dr. Jeffrey Rood


Oxovanadium(IV) complexes have numerous applications in diverse areas such as catalysts for organic transformations and as anti-fungal agents. Complexes that this research focused on have shown potential in acting as insulin mimetics. The goal of this research was to synthesis and fully characterize a new series of oxovanadium complexes and then investigate the insulin mimetic properties of the complexes with adipose cell culture work. Vanadyl complexes involving a series of salicylaldiminato ligands [C6H5N=CHC6H4OH (L1), 2,6-iPrC6H3N=CHC6H4OH (L2), C6H5N=CH-3,5-tBu2C6H2OH (L3) and 2,6-iPrC6H3N=CH-3,5-tBu2C6H2OH (L4)] were synthesized and structurally characterized. The ligand set was investigated due to the ease of sterically tuning the substituents on the ligand backbone to influence size and hydrophobicity of the resulting complexes. It is envisioned that such properties will play an important role in cellular uptake of these complexes. Reported here is the initial structural characterization of a series of complexes using FTIR and 1H-NMR spectroscopy, mass spectrometry, and X-ray crystallography.


Scholarship, Creative Arts, and Research Project (SCARP)

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