Synthesis and Characterization of Oxovanadium Compounds as Potential Insulin Mimetic Molecules
Chemistry and Biochemistry
Dr. Jeffrey Rood
Oxovanadium(IV) complexes have numerous applications in diverse areas such as catalysts for organic transformations and as anti-fungal agents. Complexes that this research focused on have shown potential in acting as insulin mimetics. The goal of this research was to synthesis and fully characterize a new series of oxovanadium complexes and then investigate the insulin mimetic properties of the complexes with adipose cell culture work. Vanadyl complexes involving a series of salicylaldiminato ligands [C6H5N=CHC6H4OH (L1), 2,6-iPrC6H3N=CHC6H4OH (L2), C6H5N=CH-3,5-tBu2C6H2OH (L3) and 2,6-iPrC6H3N=CH-3,5-tBu2C6H2OH (L4)] were synthesized and structurally characterized. The ligand set was investigated due to the ease of sterically tuning the substituents on the ligand backbone to influence size and hydrophobicity of the resulting complexes. It is envisioned that such properties will play an important role in cellular uptake of these complexes. Reported here is the initial structural characterization of a series of complexes using FTIR and 1H-NMR spectroscopy, mass spectrometry, and X-ray crystallography.
Mercando, Kaitlyn and Rood, Jeffrey A., "Synthesis and Characterization of Oxovanadium Compounds as Potential Insulin Mimetic Molecules" (2021). Summer Scholarship, Creative Arts and Research Projects (SCARP). 66.
Scholarship, Creative Arts, and Research Project (SCARP)