Document Type

Student Research Paper

Date

Fall 2022

Academic Department

Biology

Faculty Advisor(s)

Dr. Diane Bridge

Abstract

Ferroptosis is a form of regulated cell death distinct from apoptosis. It occurs in diverse animals and in plants, but has not been documented in Hydra vulgaris, a cnidarian species used for studies of stem cell biology and regeneration. Treatment with the ferroptosis-inducing chemicals diethyl maleate and Erastin caused cell death, suggesting that ferroptosis can be induced in H. vulgaris. The phenotypes are unlike those of apoptosis in H. vulgaris, and each inducer resulted in a different phenotypic response. Combining the ferroptosis inducers with ferroptosis inhibitors (Liproxstatin-1, Ferrostatin-1, and Β-mercaptoethanol) was expected to decrease cell death, however this was not observed. This research begins to characterize ferroptosis in Hydra vulgaris using ferroptosis-inducing and ferroptosis-blocking compounds.

Notes

Honors Senior Thesis

Included in

Biology Commons

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