Title

A mild halogenation of pyrazoles using sodium halide salts and Oxone

Document Type

Article

Publication Title

Tetrahedron Letters

Publication Date

1-1-2017

Abstract

A mild, inexpensive, and operationally simple pyrazole halogenation method utilizing Oxone and sodium halide salts is reported. This work documents 17 examples of alkyl, aryl, allyl, and benzyl substituted 4-chloro and 4-bromopyrazoles, obtained in up to 93% yield. Reactions are performed in water under ambient conditions and generation of organic byproducts is avoided.

Volume

58

Issue

43

First Page

4111

Last Page

4114

DOI

10.1016/j.tetlet.2017.09.042

ISSN

00404039

E-ISSN

18733581

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