Title
Transport and biological impact of manganese
Document Type
Book Chapter
Publication Title
Cellular and Molecular Biology of Metals
Publication Date
1-1-2010
Abstract
Manganese (Mn) is an essential nutrient and, unlike other trace elements (e.g., iron), toxicity is more prevalent than dietary deficiency. This chapter will commence with a discussion on the essentiality of Mn and its general biological functions. We will then discuss putative Mn transport mechanisms with a particular emphasis on the lung and brain, the primary organs involved in the etiology of Mn neurotoxicity (manganism). We conclude the chapter with several sections focusing on the neurobiology of manganism. Special emphasis is placed on the neurochemical and biochemical aspects of Mn-induced neuropathology and the biochemical similarities it shares with Parkinson’s disease (PD).
First Page
127
Last Page
142
DOI
10.1201/9781420059984
ISBN
9781420059984,9781420059977
Recommended Citation
Erikson, Keith M.; Thompson, Khristy J.; and Aschner, Michael, "Transport and biological impact of manganese" (2010). Faculty Publications. 1319.
https://jayscholar.etown.edu/facpubharvest/1319
