Title

Extended Peptide Nucleic Acid Nucleobases Based on Isoorotic Acid for the Recognition of A–U Base Pairs in Double-Stranded RNA

Document Type

Article

Publication Title

Chemistry - A European Journal

Publication Date

3-1-2021

Abstract

Peptide nucleic acids (PNA) with extended isoorotamide containing nucleobases (Io) were designed for binding A–U base pairs in double-stranded RNA. Isothermal titration calorimetry and UV thermal melting experiments revealed improved affinity for A–U using the Io scaffold in PNA. PNAs having four sequential Io extended nucleobases maintained high binding affinity.

Volume

27

Issue

13

First Page

4332

Last Page

4335

DOI

10.1002/chem.202005401

ISSN

09476539

E-ISSN

15213765

PubMed ID

33439519

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